MET and VAV2

Data Source:
BioGRID (pull down)

		MET	VAV2
Description		MET proto-oncogene, receptor tyrosine kinase	vav guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex	Cytosol Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Hepatocyte Growth Factor-activated Receptor Activity Protein Binding ATP Binding Semaphorin Receptor Activity Protein Phosphatase Binding Identical Protein Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Endothelial Cell Morphogenesis Liver Development Phagocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Negative Regulation Of Autophagy Cell Migration Peptidyl-tyrosine Phosphorylation Neuron Differentiation Pancreas Development Positive Regulation Of Microtubule Polymerization Positive Regulation Of Kinase Activity Negative Regulation Of Rho Protein Signal Transduction Entry Of Bacterium Into Host Cell Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Endothelial Cell Chemotaxis	Angiogenesis Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cell Migration Lamellipodium Assembly Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels	GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		K-252a SGX-523 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol AMG-208 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Crizotinib Cabozantinib Capmatinib Fostamatinib Tivantinib Brigatinib Amuvatinib
Diseases		Renal cell carcinoma Cholangiocarcinoma Gastric cancer
GWAS		Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 28334899) Hematocrit ( 28017375) Lung function (FEV1/FVC) ( 30804560) Medication use (beta blocking agents) ( 31015401) Multiple sclerosis (severity) ( 19010793) PR segment ( 24850809) Pulse pressure ( 30578418) Resting heart rate ( 29769521 27798624) Triglyceride levels ( 28334899) Triglycerides ( 24097068) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) vWF and FVIII levels ( 21810271)
Interacting Genes		112 interacting genes: ABL2 BAG1 BCAR3 BLK BTK CASP3 CBL CCND2 CD44 CDK4 CDK6 CDKN2B CNR1 CRK CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR EPHA2 ERBB2 FAS FES FGFR4 FGR FZR1 GAB1 GLIS2 GLMN GRB14 GRB2 GRB7 HCK HGF HGS HSH2D INPP5D INPPL1 ITGB1 ITGB4 ITK KDELR2 LATS2 LCK LYN MAP2K3 MAP2K5 MATK MUC20 MYC NCK1 NCK2 NF2 PCBD2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PLXNB1 PTK6 PTPN11 PTPRB PTPRJ RAF1 RANBP10 RANBP9 RASA1 RASSF1 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA2 SMC1A SNAPIN SNX2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SPSB1 SRC STAP1 STAT3 STK11 SYK TEC TERT TNS1 TNS2 TNS3 TNS4 TP53 TXK VAV1 VAV2 VAV3 YES1 ZAP70	66 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1
Entrez ID		4233	7410
HPRD ID		01280	02694
Ensembl ID		ENSG00000105976	ENSG00000160293
Uniprot IDs		A0A024R728 A0A024R759 B4DLF5 E6Y365 P08581	P52735
PDB IDs		1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZBX 3ZC5 3ZCL 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4IWD 4K3J 4KNB 4MXC 4O3T 4O3U 4R1V 4R1Y 4XMO 4XYF 5DG5 5EOB 5EYC 5EYD 5HLW 5HNI 5HO6 5HOA 5HOR 5HTI 5LSP 5T3Q 5UAB 5UAD 5YA5 6GCU 6I04 6SD9 6SDC 6SDD 6SDE 6UBW	2DLZ 2DM1 2LNW 2LNX 4ROJ
Enriched GO Terms of Interacting Partners?
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