VAV2 and HSPH1

Data Source:
BioGRID (two hybrid)

		VAV2	HSPH1
Description		vav guanine nucleotide exchange factor 2	heat shock protein family H (Hsp110) member 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Protein-containing Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Alpha-tubulin Binding
	Biological Process	Angiogenesis Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cell Migration Lamellipodium Assembly Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction	Receptor-mediated Endocytosis Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of NK T Cell Activation Regulation Of Cellular Response To Heat
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Central corneal thickness ( 29760442) Corneal astigmatism ( 30306274) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Multiple sclerosis ( 20598377) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) vWF and FVIII levels ( 21810271)	Metabolite levels ( 23823483)
Interacting Genes		66 interacting genes: AR ARIH1 BIRC6 BOD1L1 BRDT BZW1 CAV1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 ERBB4 FNTA FUCA1 FYN GAB1 GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MED21 MET MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1	16 interacting genes: ADD1 CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 HSPA8 NMI PAFAH1B1 PAFAH1B3 PGK1 PTEN STK39 TUBA4A UBA1 VAV2
Entrez ID		7410	10808
HPRD ID		02694	09990
Ensembl ID		ENSG00000160293	ENSG00000120694
Uniprot IDs		P52735	A0A024RDQ0 A0A024RDS1 A0A0A0MSM0 B4DY72 Q92598
PDB IDs		2DLZ 2DM1 2LNW 2LNX 4ROJ	6GFA
Enriched GO Terms of Interacting Partners?
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