MAP3K5 and TEAD2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP3K5	TEAD2
Description		mitogen-activated protein kinase kinase kinase 5	TEA domain transcription factor 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Intracellular Membrane-bounded Organelle TEAD-YAP Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Factor Activity Protein Binding Disordered Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Viral Process Cellular Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress P38MAPK Cascade Wound Healing Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notochord Development Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Embryonic Organ Development Negative Regulation Of Cell Death Protein-containing Complex Assembly Cellular Response To Retinoic Acid Regulation Of Stem Cell Differentiation
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		64 interacting genes: AKT1 ARRB1 ARRB2 AURKA CCND2 CDC25A CDK4 CDK6 CDKN1A CDKN2A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ	45 interacting genes: AKT1 ARNT AURKA BCL2L15 BECN1 C14orf39 CCND2 CDK4 CDK6 CDKN2A CDKN2B DACH1 EPHA2 FGFR4 FZR1 GLIS1 GLIS2 GNG13 HGF HIF1A INPP5A LATS2 MAP2K3 MAP2K5 MAP3K5 MYC NCOA1 NEDD4 NFIC NSD3 RAF1 RASSF1 RUNX1 SAA2 SOX3 STK11 TERT TP53 TRIM3 USF2 VGLL1 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		4217	8463
HPRD ID		03904	03432
Ensembl ID		ENSG00000197442	ENSG00000074219
Uniprot IDs		Q99683	A0A024QZE2 Q15562
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH	3L15 5DQ8 5DQE 5EMV 5HGU 6CDY 6E5G 6S60 6S64 6S66 6S69 6S6J 6UYB 6UYC 6VAH
Enriched GO Terms of Interacting Partners?
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