MAP3K5 and DMD

Data Source:
BioGRID (two hybrid)

		MAP3K5	DMD
Description		mitogen-activated protein kinase kinase kinase 5	dystrophin
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GO Annotations	Cellular Component	Cytoplasm Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex	Cytosol Cytoskeleton Cell Surface Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Z Disc Cell-substrate Junction Filopodium Filopodium Membrane Protein-containing Complex Sarcolemma Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Nitric-oxide Synthase Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Viral Process Cellular Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress P38MAPK Cascade Wound Healing Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Regulation Of Heart Rate Cytoskeleton Organization Muscle Organ Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Muscle Filament Sliding Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Cellular Protein-containing Complex Assembly Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Muscle Cell Cellular Homeostasis Muscle Fiber Development Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence	Non-integrin membrane-ECM interactions Striated Muscle Contraction
Drugs			Golodirsen
Diseases			Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM) Dilated cardiomyopathy (DCM)
GWAS		Eosinophil counts ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)
Interacting Genes		64 interacting genes: AKT1 ARRB1 ARRB2 AURKA CCND2 CDC25A CDK4 CDK6 CDKN1A CDKN2A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ	29 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 UTRN
Entrez ID		4217	1756
HPRD ID		03904	02303
Ensembl ID		ENSG00000197442	ENSG00000198947
Uniprot IDs		Q99683	A0A0S2Z3B5 A0A0S2Z3J7 A7E212 P11532 Q16484 Q4G0X0
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH	1DXX 1EG3 1EG4 3UUN
Enriched GO Terms of Interacting Partners?
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