ARVCF and TJP1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ARVCF	TJP1
Description		ARVCF delta catenin family member	tight junction protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Cytoplasm Plasma Membrane Adherens Junction	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction
	Molecular Function	Protein Binding Cadherin Binding	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Cell-cell Junction Assembly Cell Adhesion Multicellular Organism Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Hippo Signaling Maintenance Of Blood-brain Barrier Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Actin Cytoskeleton Reorganization Regulation Of Bicellular Tight Junction Assembly
Pathways			Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Central corneal thickness ( 32528159 29760442) Lymphocyte counts ( 32888494 27863252) Medication use (antihypertensives) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 28135244 27841878 28739976 30487518 30578418) Systolic blood pressure ( 27841878 30487518 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 32888494 27863252)	Central corneal thickness ( 32528159 31798171 29760442 30894546) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Interacting Genes		6 interacting genes: CDH1 CDH15 CDH2 ERBIN LNX1 TJP1	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 OCLN PEA15 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		421	7082
HPRD ID		03778	03002
Ensembl ID		ENSG00000099889	ENSG00000104067
Uniprot IDs		C9JJX6 E9PDC3 O00192	A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157 Q6MZU1
PDB IDs			2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?
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