MCC and FRAT2

Data Source:
BioGRID (two hybrid)

		MCC	FRAT2
Description		MCC regulator of WNT signaling pathway	FRAT regulator of WNT signaling pathway 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Cytoplasmic Ribonucleoprotein Granule	Cellular_component Cytoplasm Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity	Molecular_function
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Beta-catenin Destruction Complex Disassembly
Pathways			Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549)	Body mass index ( 28892062) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		79 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CSNK1E CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 IMP3 KAT5 KIF3C KIFC3 LRRC45 MAGEE1 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	12 interacting genes: BUB1 CDKN2A CTNNA1 EGFR ERBB2 GSK3B KRAS MCC MLH1 MLH3 NRAS PTPN12
Entrez ID		4163	23401
HPRD ID		01157	05419
Ensembl ID		ENSG00000171444	ENSG00000181274
Uniprot IDs		P23508	O75474
PDB IDs		6MTU 6MTV
Enriched GO Terms of Interacting Partners?
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