MAGOH and DPH2

Data Source:
BioGRID (two hybrid)

		MAGOH	DPH2
Description		mago homolog, exon junction complex subunit	diphthamide biosynthesis 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Cytosol
	Molecular Function	RNA Binding Protein Binding	Protein Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus Regulation Of Translation RNA Splicing MRNA 3'-end Processing	Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Synthesis of diphthamide-EEF2
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		19 interacting genes: ALYREF CEP70 CORO1A DPH2 DPPA4 EIF4A3 FXR1 GOLGA2 IPO13 MAP1B NXF1 PPP1R16B RBM8A TADA2A UPF3B XIST YWHAQ ZKSCAN8 ZRANB1	7 interacting genes: CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2
Entrez ID		4116	1802
HPRD ID		04005	16023
Ensembl ID		ENSG00000162385	ENSG00000132768
Uniprot IDs		P61326	B3KRB8 Q9BQC3
PDB IDs		1P27 2HYI 2J0Q 2J0S 2XB2 3EX7 7A5P
Enriched GO Terms of Interacting Partners?
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