NBR1 and FEZ1

Data Source:
HPRD (in vivo, two hybrid)

		NBR1	FEZ1
Description		NBR1 autophagy cargo receptor	fasciculation and elongation protein zeta 1
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Late Endosome Autophagosome Cytosol Membrane Nuclear Body M Band Intracellular Membrane-bounded Organelle Receptor Complex	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Microtubule Plasma Membrane Axon Dendrite Growth Cone Neuronal Cell Body
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation	Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Positive Regulation Of Neuron Differentiation Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Mitochondrion Morphogenesis Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly
Pathways		Pexophagy Pexophagy
Drugs
Diseases
GWAS			Breast cancer (survival) ( 25890600) Schizophrenia ( 22688191 23894747)
Interacting Genes		22 interacting genes: ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP1LC3B MAP2K4 METAP1 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1	57 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		4077	9638
HPRD ID		01326	09212
Ensembl ID		ENSG00000188554	ENSG00000149557
Uniprot IDs		A0A024R1V3 B7Z5R6 Q14596	Q99689
PDB IDs		1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE
Enriched GO Terms of Interacting Partners?
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