FEZ1 and RAB3GAP2

Data Source:
HPRD (two hybrid)

		FEZ1	RAB3GAP2
Description		fasciculation and elongation protein zeta 1	RAB3 GTPase activating non-catalytic protein subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Microtubule Plasma Membrane Axon Dendrite Growth Cone Neuronal Cell Body	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Enzyme Activator Activity Enzyme Regulator Activity Small GTPase Binding
	Biological Process	Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Hippocampus Development Establishment Of Cell Polarity Positive Regulation Of Neuron Differentiation Establishment Of Mitochondrion Localization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Mitochondrion Morphogenesis Cellular Response To Growth Factor Stimulus Negative Regulation Of Autophagosome Assembly	Intracellular Protein Transport Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly
Pathways			COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Martsolf syndrome
GWAS		Breast cancer (survival) ( 25890600) Schizophrenia ( 22688191 23894747)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast size ( 27182965)
Interacting Genes		57 interacting genes: BARD1 BORA BRD1 C8orf33 CCL7 CEP126 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PPP4R3B PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 STAR TAC3 TAF1D TAF9 TBC1D25 TEDC2 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251	3 interacting genes: EXOSC6 FEZ1 RAB3GAP1
Entrez ID		9638	25782
HPRD ID		09212	11471
Ensembl ID		ENSG00000149557	ENSG00000118873
Uniprot IDs		Q99689	Q9H2M9
PDB IDs
Enriched GO Terms of Interacting Partners?
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