LTBP3 and TGFB3

Data Source:
HPRD (in vivo)

		LTBP3	TGFB3
Description		latent transforming growth factor beta binding protein 3	transforming growth factor beta 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface T-tubule Platelet Alpha Granule Lumen Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix
	Molecular Function	Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Protein-containing Complex Binding Transforming Growth Factor Beta Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Transforming Growth Factor Beta Activation Positive Regulation Of Bone Resorption Bone Remodeling Elastic Fiber Assembly Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation	Activation Of MAPK Activity Response To Hypoxia In Utero Embryonic Development Platelet Degranulation Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Female Pregnancy Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Response To Laminar Fluid Shear Stress Wound Healing Regulation Of Cell Population Proliferation Odontogenesis Uterine Wall Breakdown Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Ossification Involved In Bone Remodeling Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Digestive Tract Development Embryonic Neurocranium Morphogenesis Inner Ear Development Positive Regulation Of Protein Secretion Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Secondary Palate Development Detection Of Hypoxia Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly
Pathways		Molecules associated with elastic fibres	Platelet degranulation Molecules associated with elastic fibres ECM proteoglycans
Drugs			1,4-Dioxane
Diseases		Tooth agenesis; Hypodontia	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Graft-versus-host disease Ossification of the posterior longitudinal ligament of spine (OPLL) Allograft rejection Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Acne (severe) ( 24927181) Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Osteoarthritis (hip) ( 30374069) Refractive error ( 32231278) Urate levels ( 23263486) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		12 interacting genes: CACNA1A CCNG1 GORASP2 HBEGF ITGB5 PELI2 PIK3R2 PRPF40A RAC1 TGFB1 TGFB2 TGFB3	13 interacting genes: ACVRL1 CCL20 CCN2 CHMP2A ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		4054	7043
HPRD ID		03649	01829
Ensembl ID		ENSG00000168056	ENSG00000119699
Uniprot IDs		B9EG76 Q8WYU6 Q9NS15	A5YM40 B3KVH9 P10600
PDB IDs			1KTZ 1TGJ 1TGK 2PJY 3EO1 4UM9
Enriched GO Terms of Interacting Partners?
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