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LOX and H2BC11
Data Source:
HPRD
(in vitro)
LOX
H2BC11
Description
lysyl oxidase
H2B clustered histone 11
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Extracellular Space
Nucleus
Extracellular Matrix
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Molecular Function
Protein-lysine 6-oxidase Activity
Copper Ion Binding
Protein Binding
Collagen Binding
Lipopolysaccharide Binding
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Osteoblast Differentiation
Regulation Of Protein Phosphorylation
Cellular Protein Modification Process
Heart Development
Regulation Of Gene Expression
Regulation Of Striated Muscle Tissue Development
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Peptidyl-lysine Oxidation
Protein Phosphopantetheinylation
Extracellular Matrix Organization
Collagen Fibril Organization
Bone Mineralization
Lung Development
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Ascending Aorta Development
Descending Aorta Development
Wound Healing
Response To Drug
Regulation Of Apoptotic Process
Protein Kinase B Signaling
Regulation Of Megakaryocyte Differentiation
Muscle Cell Cellular Homeostasis
Elastic Fiber Assembly
Blood Vessel Morphogenesis
Response To Steroid Hormone
Muscle Fiber Development
Cell Chemotaxis
Connective Tissue Development
DNA Biosynthetic Process
Regulation Of Receptor Binding
Regulation Of Bone Development
Cellular Response To Chemokine
Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Innate Immune Response In Mucosa
Nucleosome Assembly
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Ubiquitination
Antibacterial Humoral Response
Killing Of Cells Of Other Organism
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
Elastic fibre formation
Crosslinking of collagen fibrils
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
GWAS
Central corneal thickness (
32528159
)
Coronary artery disease (
28714974
)
Intraocular pressure (
29617998
)
Lung function (FEV1/FVC) (
30804560
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
8 interacting genes:
DHDDS
DPT
ELN
H1-1
H1-5
H2BC11
H2BC21
RAF1
4 interacting genes:
JMJD6
LOX
SPANXN2
TLX3
Entrez ID
4015
8970
HPRD ID
01087
13657
Ensembl ID
ENSG00000113083
ENSG00000124635
Uniprot IDs
B0AZT2
B7ZAJ4
D0PNI2
P28300
A0A024RCJ2
P06899
PDB IDs
2RVQ
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3W96
3W97
3W98
3W99
3WA9
3WAA
3WTP
4CAY
4YM5
4YM6
4Z5T
5AV5
5AV6
5AV8
5AV9
5AVB
5AVC
5AY8
5B0Y
5B0Z
5B24
5B2I
5B2J
5B31
5B32
5B33
5B40
5CPI
5CPJ
5CPK
5FUG
5GSE
5GTC
5GXQ
5JRG
5VEY
5X7X
5XF3
5XF4
5XF5
5Y0C
5Y0D
5Z23
5Z30
5ZBX
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6BUZ
6E0C
6E0P
6HKT
6HTS
6INQ
6IPU
6IQ4
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6JOU
6JR0
6JR1
6JXD
6K1I
6K1J
6K1K
6KVD
6KXV
6L49
6L4A
6LA8
6LA9
6M3V
6M44
6O1D
6R8Y
6R8Z
6R90
6R91
6R92
6R93
6R94
6T90
6T93
6USJ
6YOV
7C0M
7CCQ
7CCR
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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