LOX and NAMPT

Data Source:
BioGRID (proximity labelling technology)

		LOX	NAMPT
Description		lysyl oxidase	nicotinamide phosphoribosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Nucleus Extracellular Matrix	Cytosol Nuclear Speck Cell Junction Extracellular Exosome
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding Collagen Binding	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Cytokine Activity Protein Binding Identical Protein Binding Nicotinamide Phosphoribosyltransferase Activity
	Biological Process	Osteoblast Differentiation Regulation Of Protein Phosphorylation Cellular Protein Modification Process Heart Development Regulation Of Gene Expression Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-lysine Oxidation Protein Phosphopantetheinylation Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Lung Development Platelet-derived Growth Factor Receptor-beta Signaling Pathway Ascending Aorta Development Descending Aorta Development Wound Healing Response To Drug Regulation Of Apoptotic Process Protein Kinase B Signaling Regulation Of Megakaryocyte Differentiation Muscle Cell Cellular Homeostasis Elastic Fiber Assembly Blood Vessel Morphogenesis Response To Steroid Hormone Muscle Fiber Development Cell Chemotaxis Connective Tissue Development DNA Biosynthetic Process Regulation Of Receptor Binding Regulation Of Bone Development Cellular Response To Chemokine Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Signal Transduction Cell-cell Signaling Circadian Rhythm Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Circadian Regulation Of Gene Expression NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Adipose Tissue Development
Pathways		Elastic fibre formation Crosslinking of collagen fibrils	BMAL1:CLOCK,NPAS2 activates circadian gene expression Nicotinamide salvaging
Drugs			GMX1777 Daporinad
Diseases
GWAS		Central corneal thickness ( 32528159) Coronary artery disease ( 28714974) Intraocular pressure ( 29617998) Lung function (FEV1/FVC) ( 30804560) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Youthful appearance (self-reported) ( 32339537)	Grapefruit juice consumption ( 31046077)
Interacting Genes		8 interacting genes: DHDDS DPT ELN H1-1 H1-5 H2BC11 H2BC21 RAF1	5 interacting genes: ADORA2A AKT2 FANCA GGT1 USP49
Entrez ID		4015	10135
HPRD ID		01087	09938
Ensembl ID		ENSG00000113083	ENSG00000105835
Uniprot IDs		B0AZT2 B7ZAJ4 D0PNI2 P28300	A0A024R718 P43490
PDB IDs			2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB
Enriched GO Terms of Interacting Partners?
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