RHOH and GDI1

Data Source:
HPRD (in vitro)

		RHOH	GDI1
Description		ras homolog family member H	GDP dissociation inhibitor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle	Cytoplasm Golgi Apparatus Cytosol Axon Midbody Protein-containing Complex Neuronal Cell Body Myelin Sheath
	Molecular Function	GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding Kinase Inhibitor Activity Protein Kinase Binding Small GTPase Binding	GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Motor Neuron Axon Guidance Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly T Cell Differentiation Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Kinase Activity Negative Regulation Of GTPase Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Engulfment Of Apoptotic Cell Mast Cell Activation Positive Regulation Of T Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Neutrophil Migration	Signal Transduction Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Negative Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Response To Calcium Ion Negative Regulation Of Protein Targeting To Membrane
Pathways		Rho GTPase cycle	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Graves' disease ( 21841780) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		23 interacting genes: ARHGDIA ARHGDIB ARHGDIG BANP CCNH FAM90A1 GDI1 IQUB ITGB1BP1 KANK2 KCNH2 LRIF1 MBLAC1 MTX2 PLEKHA7 RIPPLY1 SCNM1 SORL1 SUOX TCF19 TGFBR1 UTP14A XPNPEP1	15 interacting genes: CDC42 EPB41 GNL1 LNX1 PSEN1 RAB1B RAB27A RAB3B RAB6A RAB9A RABAC1 RAC2 RHOH TK1 UBQLN4
Entrez ID		399	2664
HPRD ID		03616	02114
Ensembl ID		ENSG00000168421	ENSG00000203879
Uniprot IDs		Q15669 Q6ICP4	A0A0S2Z3X8 P31150
PDB IDs
Enriched GO Terms of Interacting Partners?
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