LIG1 and TUBB3

Data Source:
HPRD (two hybrid)

		LIG1	TUBB3
Description		DNA ligase 1	tubulin beta 3 class III
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Microtubule Lamellipodium Filopodium Axon Dendrite Growth Cone Extracellular Exosome
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Netrin Receptor Binding
	Biological Process	DNA Ligation Lagging Strand Elongation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Axon Guidance Netrin-activated Signaling Pathway Dorsal Root Ganglion Development
Pathways		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Bleomycin	Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome	Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS			Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)
Interacting Genes		12 interacting genes: CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 MRE11 PCNA PRKCB RGS2 TUBB3 UHRF1	34 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		3978	10381
HPRD ID		00534	04044
Ensembl ID		ENSG00000105486	ENSG00000258947
Uniprot IDs		B4DM52 F5GZ28 P18858	Q13509 Q53G92
PDB IDs		1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V	5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL
Enriched GO Terms of Interacting Partners?
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