LIG1 and DCAF7

Data Source:
BioGRID (enzymatic study)

		LIG1	DCAF7
Description		DNA ligase 1	DDB1 and CUL4 associated factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Body Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	DNA Ligation Lagging Strand Elongation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication	Multicellular Organism Development Protein Ubiquitination Post-translational Protein Modification
Pathways		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand	Association of TriC/CCT with target proteins during biosynthesis Neddylation
Drugs		Bleomycin
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Interacting Genes		12 interacting genes: CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 MRE11 PCNA PRKCB RGS2 TUBB3 UHRF1	7 interacting genes: APP ATP13A2 BMPR1B DYRK1B LIG1 PWP2 YWHAG
Entrez ID		3978	10238
HPRD ID		00534	09340
Ensembl ID		ENSG00000105486	ENSG00000136485
Uniprot IDs		B4DM52 F5GZ28 P18858	P61962
PDB IDs		1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V
Enriched GO Terms of Interacting Partners?
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