LIFR and IL31RA

Data Source:
HPRD (in vivo)

		LIFR	IL31RA
Description		LIF receptor subunit alpha	interleukin 31 receptor A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Axon Presynaptic Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding	Transcription Coactivator Activity Cytokine Receptor Activity Protein Kinase Binding Cytokine Binding Granulocyte Colony-stimulating Factor Binding
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	MAPK Cascade Glandular Epithelial Cell Differentiation Acute Inflammatory Response To Antigenic Stimulus Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Homeostatic Process Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Defense Response To Other Organism
Pathways		IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases		Stuve-Wiedemann syndrome
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Pursuit maintenance gain ( 29064472) Ulcerative colitis ( 26192919)	Crohn's disease ( 23128233)
Interacting Genes		12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	2 interacting genes: IL6ST LIFR
Entrez ID		3977	133396
HPRD ID		01048	17145
Ensembl ID		ENSG00000113594	ENSG00000164509
Uniprot IDs		A8K1Z4 P42702	B4DNJ2 Q8NI17
PDB IDs		3E0G
Enriched GO Terms of Interacting Partners?
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