IL31RA and LIFR

Data Source:
HPRD (in vivo)

		IL31RA	LIFR
Description		interleukin 31 receptor A	LIF receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Axon Presynaptic Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Cytokine Receptor Activity Protein Kinase Binding Cytokine Binding Granulocyte Colony-stimulating Factor Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding
	Biological Process	MAPK Cascade Glandular Epithelial Cell Differentiation Acute Inflammatory Response To Antigenic Stimulus Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Homeostatic Process Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Defense Response To Other Organism	Regulation Of Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling
Drugs
Diseases			Stuve-Wiedemann syndrome
GWAS		Crohn's disease ( 23128233)	Blood protein levels ( 30072576) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Pursuit maintenance gain ( 29064472) Ulcerative colitis ( 26192919)
Interacting Genes		2 interacting genes: IL6ST LIFR	12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6
Entrez ID		133396	3977
HPRD ID		17145	01048
Ensembl ID		ENSG00000164509	ENSG00000113594
Uniprot IDs		B4DNJ2 Q8NI17	A8K1Z4 P42702
PDB IDs			3E0G
Enriched GO Terms of Interacting Partners?
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