LCP2 and FYB1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		LCP2	FYB1
Description		lymphocyte cytosolic protein 2	FYN binding protein 1
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GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cell Junction Protein-containing Complex
	Molecular Function	Protein Binding	Signaling Receptor Binding Protein Binding Lipid Binding Protein-containing Complex Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Immune Response Integrin-mediated Signaling Pathway Biological_process T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	15 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC VASP WAS
Entrez ID		3937	2533
HPRD ID		03362	04107
Ensembl ID		ENSG00000043462	ENSG00000082074
Uniprot IDs		Q13094	O15117
PDB IDs		1H3H 1YWO 2EAP 2ROR	1RI9 2GTJ 2GTO
Enriched GO Terms of Interacting Partners?
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