LAMC1 and ANTXR2

Data Source:
BioGRID (pull down)

		LAMC1	ANTXR2
Description		laminin subunit gamma 1	ANTXR cell adhesion molecule 2
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Cell Adhesion Endoderm Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly	Toxin Transport
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Lanoteplase	MDX-1303
Diseases			Infantile systemic hyalinosis and juvenile hyaline fibromatosis
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) HDL cholesterol levels ( 32203549) Height ( 31562340) Hemoglobin ( 32888494) Hypertriglyceridemia ( 27599772) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463)	Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494 27863252) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: ANTXR2 APP ATF7IP CENPU LAMA5 NID1 NID2 PSMC5 SNAPIN SNX2 SRPK1 TANK UBC WASHC3	8 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 LAMB1 LAMC1 LRP6 SMAD2
Entrez ID		3915	118429
HPRD ID		01030	07452
Ensembl ID		ENSG00000135862	ENSG00000163297
Uniprot IDs		P11047 Q6NVY8	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs		5XAU	1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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