ANTXR2 and COL4A4

Data Source:
HPRD (in vitro)

		ANTXR2	COL4A4
Description		ANTXR cell adhesion molecule 2	collagen type IV alpha 4 chain
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GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Toxin Transport	Extracellular Matrix Organization Glomerular Basement Membrane Development
Pathways			Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs		MDX-1303	TRC093
Diseases		Infantile systemic hyalinosis and juvenile hyaline fibromatosis	Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494 27863252) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)	Birth weight ( 31043758) Body mass index ( 28270201 25673413) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		8 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 LAMB1 LAMC1 LRP6 SMAD2	13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI
Entrez ID		118429	1286
HPRD ID		07452	00360
Ensembl ID		ENSG00000163297	ENSG00000081052
Uniprot IDs		A4FUA5 J3KPY9 P58335 Q32Q26	P53420
PDB IDs		1SHT 1SHU 1T6B 1TZN	5NB1
Enriched GO Terms of Interacting Partners?
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