LAG3 and CENPJ

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		LAG3	CENPJ
Description		lymphocyte activating 3	centromere protein J
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Microtubule Plasma Membrane Gamma-tubulin Small Complex
	Molecular Function	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding	Transcription Coactivator Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Interleukin-2 Production Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Astral Microtubule Nucleation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Centriole Replication Microtubule Polymerization Cell Division Cilium Assembly Centriole Elongation Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization
Pathways		MHC class II antigen presentation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2
Drugs
Diseases			Seckel syndrome Primary microcephaly (MCPH)
GWAS		Blood protein levels ( 30072576)
Interacting Genes		2 interacting genes: CEBPZ CENPJ	15 interacting genes: ATN1 BCCIP CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH STAT5A STAT5B TUBG1 YWHAG YWHAZ
Entrez ID		3902	55835
HPRD ID		01077	09876
Ensembl ID		ENSG00000089692	ENSG00000151849
Uniprot IDs		P18627	A8K8P1 F6VUX8 Q9HC77
PDB IDs			5EIB 5ITZ
Enriched GO Terms of Interacting Partners?
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