LIN28B and MIR29B1

Data Source:
BioGRID (unspecified method)

		LIN28B	MIR29B1
Description		lin-28 homolog B	microRNA 29b-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol	Extracellular Space Nucleus Cytoplasm Mitochondrion Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	MiRNA Catabolic Process Pre-miRNA Processing RNA 3'-end Processing RNA Destabilization Positive Regulation Of MiRNA Catabolic Process Negative Regulation Of Pre-miRNA Processing Negative Regulation Of Primary MiRNA Processing	Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Type III Interferon Production Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of DNA Methylation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Negative Regulation Of Protein Kinase B Signaling Regulation Of Blood Vessel Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Virus Negative Regulation Of Interleukin-32 Production Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Mesenchymal Stem Cell Proliferation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Aorta Morphogenesis Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Metalloendopeptidase Activity Regulation Of Epithelium Regeneration Negative Regulation Of Metallopeptidase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Negative Regulation Of Intestinal Epithelial Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Age at voice drop ( 27182965) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Digit length ratio ( 29659830 20303062) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Height ( 28552196 20881960 25282103 25429064 23563607 18391950 18391951) Hip circumference adjusted for BMI ( 25673412) Insomnia ( 32332799) Intraocular pressure ( 29617998 30054594) Major depressive disorder ( 27479909) Menarche (age at onset) ( 19448620 19448622 19448623 27182965 21102462 23667675 29773799 25231870) Menarche and menopause (age at onset) ( 19448621) Metabolite levels ( 23823483) Neuroblastoma ( 22941191) Pubertal anthropometrics ( 23449627) Puberty onset ( 24770850) Puberty onset (breast development) ( 24770850) Schizophrenia ( 28991256 30285260) Sporadic neuroblastoma ( 28545128) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494)	Pancreatic cancer ( 25086665) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		45 interacting genes: KAT2B MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR143 MIR145 MIR15A MIR19B1 MIR200A MIR205 MIR206 MIR221 MIR25 MIR29A MIR29B1 MIR29B2 MIR31 MIR34A MIR34B MIR429 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I TRIM71	72 interacting genes: APOBEC3B C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA RBFOX2 RBM14 RBM4 RBM47 RBMS2 RTCB SF3B1 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		389421	407024
HPRD ID		13366
Ensembl ID		ENSG00000187772	ENSG00000283797
Uniprot IDs		A0A1B0GVD3 Q6ZN17
PDB IDs		4A4I
Enriched GO Terms of Interacting Partners?
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