LIN28B and TRIM71

Data Source:
BioGRID (pull down, enzymatic study)

		LIN28B	TRIM71
Description		lin-28 homolog B	tripartite motif containing 71
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol	P-body
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Translation Repressor Activity MiRNA Binding Ubiquitin Protein Ligase Activity
	Biological Process	MiRNA Catabolic Process Pre-miRNA Processing RNA 3'-end Processing RNA Destabilization Positive Regulation Of MiRNA Catabolic Process Negative Regulation Of Pre-miRNA Processing Negative Regulation Of Primary MiRNA Processing	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Neural Tube Closure Fibroblast Growth Factor Receptor Signaling Pathway MiRNA Metabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translation Neural Tube Development Production Of MiRNAs Involved In Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Destabilization Stem Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Gene Silencing By MiRNA
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Age at voice drop ( 27182965) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Digit length ratio ( 29659830 20303062) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Height ( 28552196 20881960 25282103 25429064 23563607 18391950 18391951) Hip circumference adjusted for BMI ( 25673412) Insomnia ( 32332799) Intraocular pressure ( 29617998 30054594) Major depressive disorder ( 27479909) Menarche (age at onset) ( 19448620 19448622 19448623 27182965 21102462 23667675 29773799 25231870) Menarche and menopause (age at onset) ( 19448621) Metabolite levels ( 23823483) Neuroblastoma ( 22941191) Pubertal anthropometrics ( 23449627) Puberty onset ( 24770850) Puberty onset (breast development) ( 24770850) Schizophrenia ( 28991256 30285260) Sporadic neuroblastoma ( 28545128) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494)	Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pulmonary function ( 21946350) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		45 interacting genes: KAT2B MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR143 MIR145 MIR15A MIR19B1 MIR200A MIR205 MIR206 MIR221 MIR25 MIR29A MIR29B1 MIR29B2 MIR31 MIR34A MIR34B MIR429 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I TRIM71	11 interacting genes: LIN28B MIR1-1 MIR1-2 MIR100 MIR155 MIR15A MIR18B MIR25 MIR29A MIR29B1 MIRLET7F2
Entrez ID		389421	131405
HPRD ID		13366	19029
Ensembl ID		ENSG00000187772	ENSG00000206557
Uniprot IDs		A0A1B0GVD3 Q6ZN17	Q2Q1W2
PDB IDs		4A4I
Enriched GO Terms of Interacting Partners?
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