SERP2 and CISD2

Data Source:
BioGRID (two hybrid)

		SERP2	CISD2
Description		stress associated endoplasmic reticulum protein family member 2	CDGSH iron sulfur domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Protein-containing Complex Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding	RNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Protein Glycosylation Protein Transport Endoplasmic Reticulum Unfolded Protein Response	Autophagy Of Mitochondrion Multicellular Organism Aging Regulation Of Autophagy
Pathways
Drugs
Diseases			Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Chronic obstructive pulmonary disease ( 30804561) Dupuytren's disease ( 28886342) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828)	Asthma and attention deficit hyperactivity disorder ( 31619474) Estimated glomerular filtration rate ( 31152163) Primary biliary cholangitis ( 26394269) Schizophrenia ( 28991256) Type 2 diabetes ( 28869590)
Interacting Genes		52 interacting genes: ALG10 AQP6 BIK BSCL2 CERS4 CISD2 CKB CYB561 CYBRD1 EBP ELOVL4 ERGIC3 EWSR1 FAM210B FCGR2A FNDC9 FRMD3 GET1 GKN1 GPR152 GPR42 KASH5 LHFPL5 LMNA LYVE1 MFSD14B MTIF3 MUC1 NEMP1 OPRM1 PTGES RETREG3 RNASEK SCN3B SLC10A6 SLC30A4 SLC38A1 SLC38A7 SPACA1 STOM STX1A TIMMDC1 TM4SF18 TM4SF19 TMED8 TMEM106C TMEM14B TMEM179B TMEM237 TMEM31 TMEM80 TMX2	58 interacting genes: AIG1 APOL2 APP AQP10 BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C2CD2L C4orf3 CDIPT CFHR5 CLDN10 CLN6 CYBC1 EHHADH EMD FAM241B GALNT15 GAST GPR37L1 HHATL IER3 KIR2DL3 LEPROTL1 LRP10 MAN2B2 MIP NAPB NRG4 NSG1 PGAP2 PLPP4 PLPPR2 PNKP POMGNT1 RTP2 RUSF1 SEC22A SERP2 SLC13A3 SLC35B4 SMIM1 SNORC SPP1 STX12 STX7 THSD7B TMEM187 TMEM243 TMEM43 TMEM86A TSPAN33 TTPA VAMP4 VKORC1L1 YIPF6
Entrez ID		387923	493856
HPRD ID		16590	17413
Ensembl ID		ENSG00000151778	ENSG00000145354
Uniprot IDs		Q8N6R1	Q8N5K1
PDB IDs			3FNV 4OO7 4OOA
Enriched GO Terms of Interacting Partners?
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