ZKSCAN4 and IL36RN

Data Source:
BioGRID (two hybrid)

		ZKSCAN4	IL36RN
Description		zinc finger with KRAB and SCAN domains 4	interleukin 36 receptor antagonist
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Metal Ion Binding	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Cytokine-mediated Signaling Pathway Inflammatory Response To Antigenic Stimulus Inflammatory Response Cytokine-mediated Signaling Pathway Antifungal Humoral Response Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide
Pathways		Generic Transcription Pathway	Interleukin-36 pathway
Drugs
Diseases
GWAS		Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Refractive error ( 32231278) Schizophrenia ( 30285260) Subcortical volume (MOSTest) ( 32665545)	Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Stroke ( 26089329)
Interacting Genes		22 interacting genes: CABP5 IL36RN LXN MDM4 MEOX2 OSGIN1 PGBD1 PSMA6 SCAND1 TIAM1 TRIM39 ZKSCAN7 ZNF24 ZNF397 ZNF446 ZNF483 ZNF496 ZSCAN20 ZSCAN21 ZSCAN22 ZSCAN30 ZSCAN32	18 interacting genes: AGR2 AP3M1 CNOT4 CRACR2B DDIT4L HPCA INCA1 IRAK4 MCM6 REL SH2B2 SKIL SSBP2 SSBP3 SSBP4 UBL4B ZKSCAN4 ZNF512B
Entrez ID		387032	26525
HPRD ID		15768	16112
Ensembl ID		ENSG00000187626	ENSG00000136695
Uniprot IDs		A0A0S2Z658 B7Z7H3 Q969J2	A0A024R518 Q9UBH0
PDB IDs			4P0J 4P0K 4P0L
Enriched GO Terms of Interacting Partners?
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