KNG1 and GP1BA

Data Source:
HPRD (in vitro, in vivo)

		KNG1	GP1BA
Description		kininogen 1	glycoprotein Ib platelet subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Anchored Component Of External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding	Protein Binding Thrombin-activated Receptor Activity
	Biological Process	Platelet Degranulation Inflammatory Response Negative Regulation Of Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Vasodilation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Proteolysis	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Regulation Of Megakaryocyte Differentiation Thrombin-activated Receptor Signaling Pathway Platelet Aggregation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases			Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Activated partial thromboplastin time ( 22703881 29403010 20303064) Adiponectin levels ( 20876611) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)	Blood protein levels ( 30072576 29875488) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)
Interacting Genes		28 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		3827	2811
HPRD ID		01970	01976
Ensembl ID		ENSG00000113889	ENSG00000185245
Uniprot IDs		P01042	L7UYB8 P07359
PDB IDs		1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y	1GWB 1K13 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?