TRIM73 and GNG3

Data Source:
BioGRID (two hybrid)

		TRIM73	GNG3
Description		tripartite motif containing 73	G protein subunit gamma 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Heterotrimeric G-protein Complex Plasma Membrane Postsynaptic Density Dendrite G-protein Beta/gamma-subunit Complex Cell Body
	Molecular Function	Zinc Ion Binding Ubiquitin Protein Ligase Activity	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Protein Ubiquitination	Activation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration
Pathways			Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: ARID5A BEX2 C9orf72 DDIT4L FHL2 GNG3 HGS KRT34 NTAQ1 OIP5 PNMA1 POU6F2 PRR35 PSMF1 RUSC1 TASOR2 TTC23 YPEL3	8 interacting genes: GNB1 GNB2 GNB3 GNB4 GNB5 NTAQ1 SS18L2 TRIM73
Entrez ID		375593	2785
HPRD ID		18606	12337
Ensembl ID		ENSG00000178809	ENSG00000162188
Uniprot IDs		Q86UV7	P63215
PDB IDs
Enriched GO Terms of Interacting Partners?
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