TRIM73 and C9orf72

Data Source:
BioGRID (two hybrid)

		TRIM73	C9orf72
Description		tripartite motif containing 73	C9orf72-SMCR8 complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	P-body Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytosol Cytoplasmic Stress Granule Dendrite Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Perikaryon Intracellular Membrane-bounded Organelle Axonal Growth Cone Main Axon Flemming Body Atg1/ULK1 Kinase Complex
	Molecular Function	Zinc Ion Binding Ubiquitin Protein Ligase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Protein Ubiquitination	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Stress Granule Assembly Axon Extension Regulation Of Catalytic Activity Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Regulation Of Autophagosome Assembly
Pathways
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 30976013 25442119 29566793 22959728 27455348 19734901 20801718 24931836) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)
Interacting Genes		18 interacting genes: ARID5A BEX2 C9orf72 DDIT4L FHL2 GNG3 HGS KRT34 NTAQ1 OIP5 PNMA1 POU6F2 PRR35 PSMF1 RUSC1 TASOR2 TTC23 YPEL3	14 interacting genes: APP COIL CRX EIF2B2 HMG20A NMI POP7 REL SMCR8 SMN1 SRPK1 SYN3 TRIM73 VRTN
Entrez ID		375593	203228
HPRD ID		18606	12975
Ensembl ID		ENSG00000178809	ENSG00000147894
Uniprot IDs		Q86UV7	Q96LT7
PDB IDs			6LT0 6V4U
Enriched GO Terms of Interacting Partners?
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