TOPAZ1 and WDR48

Data Source:
BioGRID (two hybrid)

		TOPAZ1	WDR48
Description		testis and ovary specific PAZ domain containing 1	WD repeat domain 48
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Lysosome Late Endosome Intracellular Membrane-bounded Organelle
	Molecular Function		DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Ubiquitin Binding
	Biological Process	Apoptotic Process Spermatid Development Spermatocyte Division NcRNA Transcription Positive Regulation Of Meiotic Cell Cycle Phase Transition	Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Spermatogenesis Single Fertilization Viral Process Protein Deubiquitination Multicellular Organism Growth Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage Skin Development Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Seminiferous Tubule Development Regulation Of Protein Monoubiquitination Positive Regulation Of Protein Deubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways			Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258)	Metabolic syndrome ( 31589552) Social communication problems ( 24564958)
Interacting Genes			7 interacting genes: FANCI NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC
Entrez ID		375337	57599
HPRD ID		19563	11146
Ensembl ID		ENSG00000173769	ENSG00000114742
Uniprot IDs		Q8N9V7	A0A024R2L1 Q8TAF3
PDB IDs			5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ
Enriched GO Terms of Interacting Partners?
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