KCNA1 and KCNA3

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KCNA1	KCNA3
Description		potassium voltage-gated channel subfamily A member 1	potassium voltage-gated channel subfamily A member 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Integral Component Of Membrane Apical Plasma Membrane Cell Junction Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Presynaptic Membrane Neuronal Cell Body Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Axon Calyx Of Held Membrane Raft Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Transmembrane Transporter Activity Disordered Domain Specific Binding Voltage-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Voltage-gated Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity
	Biological Process	Startle Response Potassium Ion Transport Regulation Of Muscle Contraction Chemical Synaptic Transmission Neuroblast Proliferation Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Cellular Protein Localization Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Regulation Of Postsynaptic Membrane Potential Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential Positive Regulation Of Voltage-gated Potassium Channel Activity	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels
Drugs		Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine	Enflurane Clofazimine Promethazine Miconazole Dalfampridine
Diseases		Episodic ataxias
GWAS			Acute lymphoblastic leukemia (childhood) ( 22076464)
Interacting Genes		16 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA3 KCNE4 MAL SGTA TMEM14B TMEM86A	10 interacting genes: BAX CAV1 CD3D DEFB4A DLG1 DLG4 DOLK IL16 KCNA1 KCNA2
Entrez ID		3736	3738
HPRD ID		08885	15937
Ensembl ID		ENSG00000111262	ENSG00000177272
Uniprot IDs		Q09470	P22001
PDB IDs		2AFL	4BGC
Enriched GO Terms of Interacting Partners?
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