INPPL1 and FLNC

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		INPPL1	FLNC
Description		inositol polyphosphate phosphatase like 1	filamin C
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GO Annotations	Cellular Component	Nucleus Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Lamellipodium Filopodium	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Actin Binding Protein Binding Hydrolase Activity SH3 Domain Binding SH2 Domain Binding	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding
	Biological Process	Endochondral Ossification Immune System Process Glucose Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Response To Insulin Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Ruffle Assembly	Cell Junction Assembly Muscle Fiber Development
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling	Cell-extracellular matrix interactions
Drugs
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Heart rate response to recovery post exercise (10 sec) ( 29497042)	Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		21 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 MET SHC1 SORBS1 SORBS3 SRC UBC	35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		3636	2318
HPRD ID		02900	00018
Ensembl ID		ENSG00000165458	ENSG00000128591
Uniprot IDs		O15357	Q14315 Q59H94
PDB IDs		2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP	1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX
Enriched GO Terms of Interacting Partners?
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