IL4 and IL4R

Data Source:
HPRD (in vitro, in vivo)

		IL4	IL4R
Description		interleukin 4	interleukin 4 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Innate Immune Response In Mucosa Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Chronic Inflammatory Response Immune Response Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Macroautophagy Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation B Cell Costimulation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation T Cell Activation Macrophage Activation Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Myeloid Dendritic Cell Differentiation Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Mast Cell Degranulation T-helper 2 Cell Differentiation Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Mononuclear Cell Migration Dendritic Cell Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cold-induced Thermogenesis Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Myoblast Fusion Positive Regulation Of Cellular Respiration Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Eosinophil Chemotaxis Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling	Interleukin-4 and Interleukin-13 signaling
Drugs		Pascolizumab	AER001 Dupilumab
Diseases		Asthma	Asthma
GWAS		Asthma ( 31959851 31619474 29273806) Asthma (childhood onset) ( 31036433 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825) Atopic march ( 26542096) Inflammatory bowel disease ( 23128233) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278)	Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		7 interacting genes: A2M CD53 FBXO7 IL13RA2 IL2RG IL4R PIK3CD	23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6
Entrez ID		3565	3566
HPRD ID		00989	00990
Ensembl ID		ENSG00000113520	ENSG00000077238
Uniprot IDs		D4HNR6 P05112 Q5FC01	B2RBY1 P24394
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7 4YDY 5FHX 6OEL	1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL
Enriched GO Terms of Interacting Partners?
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