IL4R and IL13

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		IL4R	IL13
Description		interleukin 4 receptor	interleukin 13
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Interleukin-4 Receptor Activity Protein Binding	Cytokine Activity Interleukin-13 Receptor Binding Protein Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Regulation Of Proton Transport Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of NAD(P)H Oxidase Activity Response To Nicotine Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Ethanol Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Interleukin-4 and Interleukin-13 signaling	Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling
Drugs		AER001 Dupilumab	Cintredekin Besudotox Lebrikizumab
Diseases		Asthma	Asthma Graft-versus-host disease
GWAS		Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 31361310 31959851 20860503 32296059 31619474 29785011 29273806) Asthma (childhood onset) ( 24241537 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 23886662 25574825 26482879 23727859) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 22286212 24920014) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Psoriasis ( 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Rosacea symptom severity ( 29771307)
Interacting Genes		23 interacting genes: ARIH2 CD40 DOK2 FES HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 PRKCZ PTPN11 PTPN6 RACK1 SHC1 SOCS5 STAT6	5 interacting genes: IL13RA1 IL13RA2 IL4R PIK3R1 VCAM1
Entrez ID		3566	3596
HPRD ID		00990	00981
Ensembl ID		ENSG00000077238	ENSG00000169194
Uniprot IDs		B2RBY1 P24394	P35225
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3LB6 4I77 4PS4 5E4E 5L6Y
Enriched GO Terms of Interacting Partners?
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