IHH and HHIP

Data Source:
HPRD (in vivo)

		IHH	HHIP
Description		Indian hedgehog signaling molecule	hedgehog interacting protein
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Extracellular Matrix	Extracellular Region Nucleus Cytoplasm Integral Component Of Plasma Membrane Cell Surface Ciliary Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity	Catalytic Activity Protein Binding Zinc Ion Binding Hedgehog Family Protein Binding
	Biological Process	Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Proteoglycan Metabolic Process Smoothened Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Embryonic Pattern Specification Regulation Of Gene Expression Intein-mediated Protein Splicing Protein Autoprocessing Vitelline Membrane Formation Pancreas Development Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion Liver Regeneration	Signal Transduction Neuroblast Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np RUNX2 regulates chondrocyte maturation	Ligand-receptor interactions
Drugs
Diseases		Brachydactyly, including: type A; type B; type D; type E Acrocapitofemoral dysplasia
GWAS		Height ( 20881960 31562340 18391951 18391952 20189936) Waist circumference adjusted for body mass index ( 26785701)	Adolescent idiopathic scoliosis ( 30395268) Birth weight ( 31043758 27680694) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 22080838 28166215 30804561 19300482 25101718 20173748) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Diverticular disease ( 30177863) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 30172743) Femoral neck size ( 31053729) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Infant length ( 25281659) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 31453325) Lung function (FEV1/FVC) variance ( 31453325) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Malaria ( 31844061) Offspring birth weight ( 31043758) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pre bronchodilator FEV1/FVC ratio in never-smokers ( 27612410) Pulmonary function ( 20010834 20010835 19300500) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		4 interacting genes: HHIP PTCH1 PTCH2 RHOD	3 interacting genes: DHH IHH SHH
Entrez ID		3549	64399
HPRD ID		02839	06937
Ensembl ID		ENSG00000163501	ENSG00000164161
Uniprot IDs		Q14623	Q96QV1
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P	2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5
Enriched GO Terms of Interacting Partners?
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