IHH and RHOD

Data Source:
BioGRID (two hybrid)

		IHH	RHOD
Description		Indian hedgehog signaling molecule	ras homolog family member D
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Extracellular Matrix	Early Endosome Cytosol Cytoskeleton Plasma Membrane Cell Cortex Endosome Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity	GTPase Activity GTP Binding Protein Kinase Binding
	Biological Process	Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Proteoglycan Metabolic Process Smoothened Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Embryonic Pattern Specification Regulation Of Gene Expression Intein-mediated Protein Splicing Protein Autoprocessing Vitelline Membrane Formation Pancreas Development Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion Liver Regeneration	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Regulation Of Cell Shape Cell Migration Lamellipodium Assembly Positive Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Focal Adhesion Assembly Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np RUNX2 regulates chondrocyte maturation	Rho GTPase cycle RHO GTPases Activate Formins
Drugs
Diseases		Brachydactyly, including: type A; type B; type D; type E Acrocapitofemoral dysplasia
GWAS		Height ( 20881960 31562340 18391951 18391952 20189936) Waist circumference adjusted for body mass index ( 26785701)	Height ( 20881960 25282103)
Interacting Genes		4 interacting genes: HHIP PTCH1 PTCH2 RHOD	13 interacting genes: ACVR1 ADCK5 ADRB2 ANKFY1 BMPR1B DIAPH2 HRAS IHH PLXNA1 SMAD2 SMAD4 SMURF2 TGFBR1
Entrez ID		3549	29984
HPRD ID		02839	05776
Ensembl ID		ENSG00000163501	ENSG00000173156
Uniprot IDs		Q14623	E9PIG5 O00212
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P	2J1L
Enriched GO Terms of Interacting Partners?
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