HCN1 and HCN2

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		HCN1	HCN2
Description		hyperpolarization activated cyclic nucleotide gated potassium channel 1	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite HCN Channel Complex	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex HCN Channel Complex
	Molecular Function	Intracellular CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Voltage-gated Cation Channel Activity CAMP Binding Identical Protein Binding	Intracellular CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding CAMP Binding Identical Protein Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Apical Protein Localization Retinal Cone Cell Development Protein Homotetramerization Cellular Response To CAMP Potassium Ion Transmembrane Transport	Cell-cell Signaling Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		HCN channels	HCN channels
Drugs			Cyclic GMP Cyclic adenosine monophosphate Ivabradine
Diseases
GWAS		Adventurousness ( 30643258) Age at first birth ( 27798627) Age at first sexual intercourse ( 27089180) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Electrocardiographic traits ( 32602732) Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Irritable mood ( 29500382) Non-response to bupropion and depression ( 27622933) Number of sexual partners ( 30643258) P wave duration ( 28794112) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Spatial memory ( 31596458) Squamous cell lung carcinoma ( 28604730) Survival in colon cancer ( 25866641) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)
Interacting Genes		2 interacting genes: HCN2 PEX5L	2 interacting genes: HCN1 HCN4
Entrez ID		348980	610
HPRD ID		09099	07213
Ensembl ID		ENSG00000164588	ENSG00000099822
Uniprot IDs		O60741 Q86WJ6	Q9UL51
PDB IDs		5U6O 5U6P 6UQF 6UQG	2MPF 3U10
Enriched GO Terms of Interacting Partners?
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