HCN1 and PEX5L

Data Source:
BioGRID (pull down)

		HCN1	PEX5L
Description		hyperpolarization activated cyclic nucleotide gated potassium channel 1	peroxisomal biogenesis factor 5 like
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite HCN Channel Complex	Peroxisomal Membrane Cytosol Receptor Complex
	Molecular Function	Intracellular CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Voltage-gated Cation Channel Activity CAMP Binding Identical Protein Binding	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Small GTPase Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Apical Protein Localization Retinal Cone Cell Development Protein Homotetramerization Cellular Response To CAMP Potassium Ion Transmembrane Transport	Protein Import Into Peroxisome Matrix, Docking Regulation Of CAMP-mediated Signaling
Pathways		HCN channels
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age at first birth ( 27798627) Age at first sexual intercourse ( 27089180) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Electrocardiographic traits ( 32602732) Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Irritable mood ( 29500382) Non-response to bupropion and depression ( 27622933) Number of sexual partners ( 30643258) P wave duration ( 28794112) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Spatial memory ( 31596458) Squamous cell lung carcinoma ( 28604730) Survival in colon cancer ( 25866641) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)	Bipolar disorder ( 31043756) Blood metabolite levels ( 24816252) Childhood body mass index ( 33045005) Glucose homeostasis traits ( 25524916) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 21490949)
Interacting Genes		2 interacting genes: HCN2 PEX5L	3 interacting genes: HCN1 PEX7 RAF1
Entrez ID		348980	51555
HPRD ID		09099	11425
Ensembl ID		ENSG00000164588	ENSG00000114757
Uniprot IDs		O60741 Q86WJ6	Q8IYB4
PDB IDs		5U6O 5U6P 6UQF 6UQG
Enriched GO Terms of Interacting Partners?
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