IGFBP6 and UBAC1

Data Source:
BioGRID (two hybrid)

		IGFBP6	UBAC1
Description		insulin like growth factor binding protein 6	UBA domain containing 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex	Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding	Protein Binding
	Biological Process	Activation Of MAPK Activity Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway	Protein Ubiquitination
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		37 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 EFEMP1 EFEMP2 ENKD1 EPDR1 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587	34 interacting genes: AIRE APP ARRDC3 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBB UBC UBQLN2 ZDHHC17 ZG16B
Entrez ID		3489	10422
HPRD ID		00902	12170
Ensembl ID		ENSG00000167779	ENSG00000130560
Uniprot IDs		P24592	A0A140VK64 Q9BSL1
PDB IDs		1RMJ	2DAI
Enriched GO Terms of Interacting Partners?
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