IFNGR2 and GRIK1

Data Source:
HPRD (in vitro)

		IFNGR2	GRIK1
Description		interferon gamma receptor 2	glutamate ionotropic receptor kainate type subunit 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Membrane
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway	Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Central Nervous System Development Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs		Interferon gamma-1b	Glutamic acid Butabarbital Topiramate Tezampanel
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Forehead morphology ( 29921221) Generalized epilepsy ( 30531953) Glucocorticoid-induced osteonecrosis ( 26265699) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Periodontitis (DPAL) ( 24024966) Plasma parathyroid hormone levels ( 30134803) Refractive error ( 32231278) Response to statin therapy ( 20339536) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24	8 interacting genes: CYSLTR2 DLG4 FLNA GRIP1 HOMER1 PICK1 SDCBP TAAR1
Entrez ID		3460	2897
HPRD ID		00956	00693
Ensembl ID		ENSG00000159128	ENSG00000171189
Uniprot IDs		A8K881 E7EUY1 P38484	B7Z256 B7Z3V7 E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086
PDB IDs		5EH1 6E3K 6E3L	2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
Enriched GO Terms of Interacting Partners?
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