IFNGR2 and CCT8

Data Source:
BioGRID (affinity chromatography technology)

		IFNGR2	CCT8
Description		interferon gamma receptor 2	chaperonin containing TCP1 subunit 8
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Zona Pellucida Receptor Complex Extracellular Region Nucleoplasm Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cilium Secretory Granule Lumen Azurophil Granule Lumen Cell Body Intermediate Filament Cytoskeleton Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding	Protein Binding ATP Binding ATPase Activity Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Neutrophil Degranulation Pore Complex Assembly Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24	3 interacting genes: ACTB APP PTEN
Entrez ID		3460	10694
HPRD ID		00956	10816
Ensembl ID		ENSG00000159128	ENSG00000156261
Uniprot IDs		A8K881 E7EUY1 P38484	P50990 Q7Z759
PDB IDs		5EH1 6E3K 6E3L	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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