IFNA1 and CR2

Data Source:
HPRD (in vivo)

		IFNA1	CR2
Description		interferon alpha 1	complement C3d receptor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Protein Binding	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Blood Coagulation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Defense Response To Virus Type I Interferon Signaling Pathway	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation Regulation Of Complement Activation B Cell Proliferation Viral Entry Into Host Cell
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production	Regulation of Complement cascade
Drugs
Diseases
GWAS			Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)
Interacting Genes		4 interacting genes: CR2 IFNAR1 IL2 IRF9	10 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53
Entrez ID		3439	1380
HPRD ID		00974	00399
Ensembl ID		ENSG00000197919	ENSG00000117322
Uniprot IDs		L0N195 P01562	P20023
PDB IDs		3UX9	1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED
Enriched GO Terms of Interacting Partners?
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