ATXN1L and HLX

Data Source:
BioGRID (two hybrid)

		ATXN1L	HLX
Description		ataxin 1 like	H2.0 like homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Dendrite	Chromatin Nucleus
	Molecular Function	DNA Binding RNA Binding Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Brain Development Learning Memory Extracellular Matrix Organization Social Behavior Lung Alveolus Development Anatomical Structure Development Positive Regulation Of Hematopoietic Stem Cell Proliferation	Liver Development Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Population Proliferation Cell Differentiation Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Organ Growth Enteric Nervous System Development Embryonic Digestive Tract Morphogenesis
Pathways
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Apolipoprotein B levels ( 32203549) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal fluid AB1-42 levels ( 26252872) Diverticular disease ( 30177863) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Granulocyte percentage of myeloid white cells ( 27863252) Lung function (FVC) ( 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) PR interval ( 32439900) Triglyceride levels ( 32154731) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 32888494)
Interacting Genes		83 interacting genes: ACO2 ACOT7 ADORA1 AFAP1L2 AGXT ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ARID5A ATXN1 C1orf94 CAMSAP2 CBFA2T2 CDSN CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FAM168A FOXH1 FUS GAS7 GMEB2 GORASP2 GPATCH8 HGS HIVEP1 HLX HSFX1 KRTAP11-1 KRTAP13-1 KRTAP19-7 KRTAP21-2 KRTAP8-1 LARP4B MACROH2A1 MATN2 MBD1 MBD6 MEIS3 MEOX2 METTL17 METTL27 MYOZ3 NBR1 NCOR1 NCOR2 NIT1 NUTM2F PHPT1 PICALM PICK1 PRRC2B RAD54L2 RBFOX1 RBFOX2 RRAGC SCAF11 SHISA2 SMARCC2 SREBF1 ST6GALNAC6 STAC2 SUGP2 TBX2 TEX37 THY1 TMEM25 TMEM8B TRIP11 UNKL USP54 YPEL3 YY1AP1 ZBTB32 ZC3H7B ZSWIM8	13 interacting genes: ATXN1L C14orf119 CALCOCO2 CYSRT1 DTX2 FOXH1 LONRF1 MIEN1 PRR20A PRR20B PRR20C PRR20D PRR20E
Entrez ID		342371	3142
HPRD ID		19555	00875
Ensembl ID		ENSG00000224470	ENSG00000136630
Uniprot IDs		P0C7T5	Q14774
PDB IDs
Enriched GO Terms of Interacting Partners?
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