TRIM38 and HSPA1L

Data Source:
BioGRID (two hybrid)

		TRIM38	HSPA1L
Description		tripartite motif containing 38	heat shock protein family A (Hsp70) member 1 like
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleoplasm Cytoplasm Cytosol	Zona Pellucida Receptor Complex Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Plasma Membrane COP9 Signalosome Cell Body Blood Microparticle
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding ATPase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway	Response To Unfolded Protein Binding Of Sperm To Zona Pellucida Vesicle-mediated Transport Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Interferon gamma signaling	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Fish- and plant-related diet ( 32066663) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)
Interacting Genes		30 interacting genes: ATXN1 BYSL EIF1B GMCL1 GORASP2 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 MTURN PIAS4 PSMA4 RFC5 RIPK1 RNF4 SDCBP STXBP1 TCEA2 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U ZNF764	5 interacting genes: BAG4 HRAS LINC01554 PTPRF TRIM38
Entrez ID		10475	3305
HPRD ID		15555	00776
Ensembl ID		ENSG00000112343	ENSG00000204390
Uniprot IDs		A0A024QZY4 O00635	A0A1U9X7W7 P34931
PDB IDs			3GDQ
Enriched GO Terms of Interacting Partners?
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