HSPA1L and TRIM38

Data Source:
BioGRID (two hybrid)

		HSPA1L	TRIM38
Description		heat shock protein family A (Hsp70) member 1 like	tripartite motif containing 38
Image			No pdb structure
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Plasma Membrane COP9 Signalosome Cell Body Blood Microparticle	Cellular_component Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding ATPase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Response To Unfolded Protein Binding Of Sperm To Zona Pellucida Vesicle-mediated Transport Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat Positive Regulation Of Protein Targeting To Mitochondrion	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation	Interferon gamma signaling
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Fish- and plant-related diet ( 32066663) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: BAG4 HRAS LINC01554 PTPRF TRIM38	30 interacting genes: ATXN1 BYSL EIF1B GMCL1 GORASP2 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 MTURN PIAS4 PSMA4 RFC5 RIPK1 RNF4 SDCBP STXBP1 TCEA2 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U ZNF764
Entrez ID		3305	10475
HPRD ID		00776	15555
Ensembl ID		ENSG00000204390	ENSG00000112343
Uniprot IDs		A0A1U9X7W7 P34931	A0A024QZY4 O00635
PDB IDs		3GDQ
Enriched GO Terms of Interacting Partners?
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