HPCAL1 and CA3

Data Source:
BioGRID (two hybrid)

		HPCAL1	CA3
Description		hippocalcin like 1	carbonic anhydrase 3
Image
GO Annotations	Cellular Component	Membrane	Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Nickel Cation Binding Phosphatase Activity Hydro-lyase Activity
	Biological Process		One-carbon Metabolic Process Response To Oxidative Stress Response To Bacterium Bicarbonate Transport Dephosphorylation Response To Ethanol
Pathways			Reversible hydration of carbon dioxide
Drugs			Topiramate Ethoxzolamide Sulpiride Celecoxib Benzthiazide Valdecoxib Cyclothiazide Methazolamide Acetazolamide Dorzolamide Zonisamide Diclofenamide Brinzolamide Ellagic acid Saccharin
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Kidney function decline traits ( 25493955) Lung function (FEV1/FVC) ( 30061609) Platelet distribution width ( 32888494)	Blood protein levels ( 30072576 29875488 28240269) Blood trace element (Zn levels) ( 23720494) Estimated glomerular filtration rate ( 31152163) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252)
Interacting Genes		38 interacting genes: AMOT ATXN1 C19orf44 C1QTNF2 CA3 COLGALT2 CREM DTX2 EFEMP2 EPHB3 FZD7 GATA5 HMG20A IKBKG KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP4-2 KRTAP5-9 LITAF MDFI MICOS10-NBL1 MYDGF NBL1 NBPF19 NOTCH2NLA PLAAT2 SERPINI2 SLC34A1 TPSG1 VWC2 ZNF655	3 interacting genes: HPCAL1 LXN SRC
Entrez ID		3241	761
HPRD ID		02564	00260
Ensembl ID		ENSG00000115756	ENSG00000164879
Uniprot IDs		O75544 P37235 Q6FGY1	P07451 V9HWA3
PDB IDs		5T7C	1Z93 1Z97 2HFW 3UYN 3UYQ
Enriched GO Terms of Interacting Partners?
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