APC and DLGAP1

Data Source:
HPRD (in vivo)

		APC	DLGAP1
Description		APC regulator of WNT signaling pathway	DLG associated protein 1
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GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Lateral Plasma Membrane Catenin Complex Lamellipodium Beta-catenin Destruction Complex Ruffle Membrane Perinuclear Region Of Cytoplasm Wnt Signalosome	Cellular_component Plasma Membrane Postsynaptic Density Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding	Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Mitotic Cytokinesis Cell Fate Specification Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Cell Adhesion Pattern Specification Process Nervous System Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Cell Death Wnt Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein-containing Complex Assembly Bicellular Tight Junction Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Centrosome Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chemical Synaptic Transmission Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Pathways		Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases		Familial adenomatous polyposis Esophageal cancer Gastric cancer Cancer of the anal canal Gallbladder cancer
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body mass index ( 29273807) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Reaction time ( 29844566) Total body bone mineral density ( 29304378)	Alanine aminotransferase levels ( 31219225) Body fat mass ( 28552196) Cardiac Troponin-T levels ( 23247143) Eating disorders ( 22911880) Economic and political preferences (time) ( 22566634) Erythrocyte cadmium concentration in never smokers ( 27005419) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) Initial alcohol sensitivity ( 30276832) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 27182965 25231870) Midgestational circulating levels of PBDEs ( 28235828) Obesity-related traits ( 23251661) Plasma free amino acid levels ( 30659259) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Trunk fat mass ( 28552196) Upper eyelid sagging severity ( 24869959)
Interacting Genes		138 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANP32B ANXA7 AP2B1 ARHGEF4 ASAP2 AXIN1 AXIN2 BAAT BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNA1 CTNNB1 CTSV CYP17A1 CYTH2 DIRAS3 DKK3 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FAM214A FANCC FBP1 FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIAA1328 KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT19 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAP2K1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NANS NAT2 NAV1 NAV2 NAV3 NCKAP5 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PPP3R2 PRKACA PSMD1 PTPN13 RANBP9 RASA1 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMAD1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TGFB1 TMEFF1 TMOD1 TPR TRIM21 TRIM25 TSTD2 TUBA4A XPO1 YWHAQ ZNF106 ZNF510	24 interacting genes: APC DLG1 DLG2 DLG3 DLG4 DLGAP2 DLGAP3 DYNLL1 DYNLL2 FHL2 GRB2 GRIN2A GRIN2C ITSN1 ITSN2 KCNA4 MAGEA11 MAGI2 MYO5A SHANK1 SHANK2 SHANK3 SORBS2 TANC1
Entrez ID		324	9229
HPRD ID		01439	09260
Ensembl ID		ENSG00000134982	ENSG00000170579
Uniprot IDs		P25054 Q4LE70	A0A0A0MTP4 A8MXQ8 B7Z2J5 O14490 Q6IS01
PDB IDs		1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H	5YPO
Enriched GO Terms of Interacting Partners?
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