DLGAP1 and GRIN2C

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		DLGAP1	GRIN2C
Description		DLG associated protein 1	glutamate ionotropic receptor NMDA type subunit 2C
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Plasma Membrane Postsynaptic Density Glutamatergic Synapse Postsynaptic Specialization	Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity	NMDA Glutamate Receptor Activity Protein Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Chemical Synaptic Transmission Regulation Of Postsynaptic Neurotransmitter Receptor Activity	Glutamate Receptor Signaling Pathway Brain Development Response To Wounding Calcium-mediated Signaling Directional Locomotion Ionotropic Glutamate Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Regulation Of Synaptic Plasticity Neuromuscular Process Controlling Balance Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Alanine aminotransferase levels ( 31219225) Body fat mass ( 28552196) Cardiac Troponin-T levels ( 23247143) Eating disorders ( 22911880) Economic and political preferences (time) ( 22566634) Erythrocyte cadmium concentration in never smokers ( 27005419) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) Initial alcohol sensitivity ( 30276832) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 27182965 25231870) Midgestational circulating levels of PBDEs ( 28235828) Obesity-related traits ( 23251661) Plasma free amino acid levels ( 30659259) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Trunk fat mass ( 28552196) Upper eyelid sagging severity ( 24869959)	Congenital heart disease (maternal effect) ( 28468790)
Interacting Genes		24 interacting genes: APC DLG1 DLG2 DLG3 DLG4 DLGAP2 DLGAP3 DYNLL1 DYNLL2 FHL2 GRB2 GRIN2A GRIN2C ITSN1 ITSN2 KCNA4 MAGEA11 MAGI2 MYO5A SHANK1 SHANK2 SHANK3 SORBS2 TANC1	6 interacting genes: DLG3 DLG4 DLGAP1 ERBIN IL16 PATJ
Entrez ID		9229	2905
HPRD ID		09260	00699
Ensembl ID		ENSG00000170579	ENSG00000161509
Uniprot IDs		A0A0A0MTP4 A8MXQ8 B7Z2J5 O14490 Q6IS01	H0Y2V8 O15398 Q14957 Q8IW23
PDB IDs		5YPO
Enriched GO Terms of Interacting Partners?
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