APBB1 and SF3B3

Data Source:
BioGRID (pull down)

		APBB1	SF3B3
Description		amyloid beta precursor protein binding family B member 1	splicing factor 3b subunit 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Synapse	Nucleus Nucleoplasm U2 SnRNP U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Amyloid-beta Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Histone Binding Low-density Lipoprotein Particle Receptor Binding Proline-rich Region Binding	Nucleic Acid Binding Protein Binding U2 SnRNA Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Negative Regulation Of Protein Catabolic Process
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs			Quercetin
Diseases
GWAS		Blood protein levels ( 29875488) Malaria ( 31844061)	Brain morphology (MOSTest) ( 32665545) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061)
Interacting Genes		69 interacting genes: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ARF6 ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TENM1 TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	104 interacting genes: APBB1 EFTUD2 EPS8 ERCC6 ERG HCK HGS HSPB1 KLF10 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MPP3 NAGK NOL12 OSGEP PHF5A PPIL1 PRPF40A RAD9A RBM6 RUFY2 SF3B1 SF3B6 SMAD5 SNRNP200 SREK1 TAF9 TCERG1 TOE1 U2AF2 WBP4 WWOX YWHAG ZNF579
Entrez ID		322	23450
HPRD ID		04087	12027
Ensembl ID		ENSG00000166313	ENSG00000189091
Uniprot IDs		B7Z4M9 O00213	A8K6V3 Q15393
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH	5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q
Enriched GO Terms of Interacting Partners?
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