HOXA1 and STX11

Data Source:
BioGRID (two hybrid)

		HOXA1	STX11
Description		homeobox A1	syntaxin 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Golgi Apparatus Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane SNARE Complex Presynaptic Active Zone Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Sensory Perception Of Sound Optokinetic Behavior Anatomical Structure Morphogenesis Abducens Nerve Formation Outer Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cochlea Development Cochlea Morphogenesis	Intracellular Protein Transport Exocytosis Vesicle Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome	Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Chronic venous disease ( 28374850) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Small cell lung carcinoma ( 28604730) Tonsillectomy ( 27182965 28928442)	Nicotine dependence symptom count ( 25555482) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		292 interacting genes: ADAM12 ADAMTSL4 AGXT ALG13 ALPP AMMECR1 AMOT ANKS1A ARID5A ARMC7 ATG9B ATP23 BAG4 BAHD1 BATF2 BHLHB9 BLCAP BLZF1 BSCL2 BUD31 C11orf1 C11orf16 CATSPER1 CCDC120 CCDC33 CCN3 CCN4 CCN5 CCNK CD164 CDPF1 CERCAM CFP CHIC2 CHRD CHRDL2 CNFN CNNM3 COL8A1 CREB5 CUTA CXCL16 CYHR1 CYP21A2 CYSRT1 DOCK2 DOCK3 DOK3 DTX2 DUSP10 DUSP22 EFEMP1 EFEMP2 EGFL7 ENKD1 EPDR1 ESM1 ESR2 EVA1B FAAP100 FAM219B FAM221A FBLN1 FHL3 FHL5 FOXH1 FOXN1 FRS3 FST FUCA2 GAS8 GATA1 GCM2 GDF15 GNE GP9 GPS2 GRN GSTP1 GUCD1 HEXB HEXIM2 HEY2 HOXB9 HR HSD3B7 ID3 IGFL1 IGFN1 INCA1 INO80B IRX6 ITGB4 KCTD9 KDM1A KPRP KRT31 KRT33B KRT34 KRT35 KRT37 KRT38 KRT40 KRT81 KRT82 KRT83 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP23-1 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3C LCE3E LCE4A LCE5A LGALS13 LGALS4 LMX1B LNX1 LONRF1 LPXN MACO1 MAPKBP1 MDFI MFAP2 MGAT5B MKRN3 MYO15B MYPOP N4BP2L2 NBPF19 NCK2 NECTIN2 NEDD9 NEK6 NELL2 NFKBID NOTCH2NLA NR1D2 NTN4 NXF1 ODF1 OIT3 P2RY6 PAX6 PBX2 PCSK5 PCYOX1 PHETA1 PIK3R1 PIN1 PITX1 PITX2 PKNOX1 PLEKHN1 PLLP PLSCR1 PLSCR2 PLSCR3 PLSCR4 PPP1R32 PRICKLE4 PRMT6 PROP1 PSMB1 PTH1R PVR QARS1 RALGDS RANBP3 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS19 RGS20 RNF208 RSPO2 RTN4R SCT SDCBP SIVA1 SLC15A3 SLC23A1 SLIT1 SLPI SNRPB SNRPC SPATA12 SPATA18 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D SSUH2 STX11 SUV39H1 TBC1D10C TBX15 TCF19 TCF3 TEKT4 TEKT5 TGFB1 TGM7 THAP7 TLE5 TNS2 TRAF1 TRAF2 TRAF4 TRAPPC6A TRIM42 TRIM55 TRIM63 TRIM8 TRIP6 TSPAN4 UBL5 UNKL VASN VWC2 VWC2L WDR83 WWOX YIPF3 YPEL3 ZBTB16 ZIM2 ZMAT1 ZNF417 ZNF587 ZNF688 ZNF774 ZNF837 ZNF843	97 interacting genes: APP AXIN1 AXIN2 BLOC1S6 BYSL C1orf109 CARD9 CCBE1 CCDC120 CCDC125 CCDC184 CCDC196 CCDC33 CCHCR1 CCNK CDCA7L CDR2L CRYBA4 CTBP2 CWF19L2 DISC1 DUSP29 EIF1AD EIF2B5 FAM110A FAM161A FAM161B FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS HOXA1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KIFC3 KLC3 KRT75 KXD1 LENG1 LONRF1 MAGOHB MBD3L1 MBIP MEOX2 MFAP1 MID2 MIS18A NDC80 NTAQ1 PKN1 PPP1R18 PRKAB2 PRPF18 PRPF31 PSMA3 PSMC3 RAD51D RNF6 RNF8 RNPS1 RUNX1T1 SCNM1 SH2D4A SHC3 SIKE1 SLC38A2 SMARCE1 SNAP23 SNAP25 SNX3 SOGA1 STX1A STX4 SUV39H1 TADA3 TAF6L TBK1 TCEA2 TCF4 TLE5 TNFRSF21 TRIM41 TSGA10IP UBASH3A USHBP1 VAMP2 VPS52 ZCCHC10 ZNF19 ZNF417 ZNF587
Entrez ID		3198	8676
HPRD ID		00843	09231
Ensembl ID		ENSG00000105991	ENSG00000135604
Uniprot IDs		P49639	O75558
PDB IDs
Enriched GO Terms of Interacting Partners?
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