STX11 and PKN1

Data Source:
BioGRID (two hybrid)

		STX11	PKN1
Description		syntaxin 11	protein kinase N1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane SNARE Complex Presynaptic Active Zone Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding Nuclear Receptor Coactivator Activity Small GTPase Binding Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Androgen Receptor Binding
	Biological Process	Intracellular Protein Transport Exocytosis Vesicle Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Spleen Development Regulation Of Cell Motility
Pathways			RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs			Fostamatinib
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Nicotine dependence symptom count ( 25555482) Pre-treatment viral load in HIV-1 infection ( 31219150)	Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		97 interacting genes: APP AXIN1 AXIN2 BLOC1S6 BYSL C1orf109 CARD9 CCBE1 CCDC120 CCDC125 CCDC184 CCDC196 CCDC33 CCHCR1 CCNK CDCA7L CDR2L CRYBA4 CTBP2 CWF19L2 DISC1 DUSP29 EIF1AD EIF2B5 FAM110A FAM161A FAM161B FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS HOXA1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KIFC3 KLC3 KRT75 KXD1 LENG1 LONRF1 MAGOHB MBD3L1 MBIP MEOX2 MFAP1 MID2 MIS18A NDC80 NTAQ1 PKN1 PPP1R18 PRKAB2 PRPF18 PRPF31 PSMA3 PSMC3 RAD51D RNF6 RNF8 RNPS1 RUNX1T1 SCNM1 SH2D4A SHC3 SIKE1 SLC38A2 SMARCE1 SNAP23 SNAP25 SNX3 SOGA1 STX1A STX4 SUV39H1 TADA3 TAF6L TBK1 TCEA2 TCF4 TLE5 TNFRSF21 TRIM41 TSGA10IP UBASH3A USHBP1 VAMP2 VPS52 ZCCHC10 ZNF19 ZNF417 ZNF587	83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC103 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TRIM27 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1
Entrez ID		8676	5585
HPRD ID		09231	03019
Ensembl ID		ENSG00000135604	ENSG00000123143
Uniprot IDs		O75558	Q16512
PDB IDs			1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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